Midline destructive lesions: A diagnostic challenge

Midline destructive lesions (MDLs) are a diagnostic challenge due to an extensive differential diagnosis and vague presenting signs symptoms. It may be neoplastic, autoimmune, traumatic, infectious, or unknown. The lethal characterized by ulcerative destruction of midline structures the face like nose, paranasal sinus palate. A spectrum diseases with myriad clinicopathological features can present as lesions. Immunohistochemistry has played major role in discerning wide range into specific categories over years.